This study aimed at estimating the anti-cancer potentials of Propolis, Egyptian bee venom on the colorectal cancer cell line HCT-116. The Egyptian bee venom showed higher toxicity on cells. After 24 hrs post treatment with Egyptian bee venom, mellitin, honey and propolis affected HCT-116 cells viability in a dose dependent manner. Our data showed a significant inhibitory effect on cells proliferation accompanied with some morphological changes. Also, up regulation of both P53 and Bax accompanied with down regulation of Bcl-2 were detected after 24 hrs post cellular treatment. Data recorded revealed that treatment with bee venom, mellitin, honey and propolis in addition to cisplatin showed clear anticancer potentials based on the up / down regulation of pro-apoptotic and anti-apoptotic genes. By bee venom, mellitin, honey and propolis induced apoptosis in HCT-116 cells which might be related to a mitochondrial-dependent pathway.
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